Summary for peptidase M14.001: carboxypeptidase A1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecarboxypeptidase A1
Other namescarboxypolypeptidase, carboxypeptidase A, CPA1 g.p. (Homo sapiens), pancreatic, pancreatic carboxypeptidase A
Domain architecture
MEROPS Classification
Classification Clan MC >> Subclan (none) >> Family M14 >> Subfamily A >> M14.001
Holotypecarboxypeptidase A1 (Bos taurus), Uniprot accession P00730 (peptidase unit: 111-419), MERNUM MER0001191
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00206
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.1
EnzymologyBRENDA database
PhysiologyRole in mammalian alimentary digestion.
Pathways KEGGPancreatic secretion
KEGGProtein digestion and absorption
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Carboxypeptidase_A
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/G/GFScissile bondfw/-/-/- (based on 16 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 5 8 0 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 0 1 0 0 0
Val 0 0 0 0 2 0 0 0
Leu 0 0 0 0 2 0 0 0
Ile 0 0 0 0 1 0 0 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 0 7 6 0 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 3 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CPA1 7q32 ENSG00000091704 1357 CPA1 114850
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Cpa 6 ENSMUSG00000054446 12872 MGI:88478