Summary for peptidase M49.001: dipeptidyl-peptidase III

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namedipeptidyl-peptidase III
Other namesdipeptidyl aminopeptidase III, dipeptidyl arylamidase III, DPP III, enkephalinase B, red cell angiotensinase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M49 >> Subfamily (none) >> M49.001
Holotypedipeptidyl-peptidase III (Rattus norvegicus), Uniprot accession O55096 (peptidase unit: 425-663), MERNUM MER0003564
History Identifier created: MEROPS 3.4 (5 November 1999)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00259
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.14 (Dipeptidyl-peptidase and tripeptidyl-peptidases) >> Peptidase 3.4.14.4
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
Activity statushuman: active (Chen & Barrett, 2004)
mouse: active (by similarity to rat) (Hirose et al., 2001)
Other databases TREEFAMhttp://www.treefam.org/family/TF300598
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/rScissile bond-/-/-/- (based on 24 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 1 2 2 1 1 0
Pro 0 0 0 0 0 2 2 1
Ala 0 0 3 2 1 3 0 1
Val 0 0 3 1 3 0 1 0
Leu 0 0 3 1 1 0 1 1
Ile 0 0 0 1 1 1 1 0
Met 0 0 1 0 1 0 0 0
Phe 0 0 1 2 2 2 2 2
Tyr 0 0 2 3 1 2 0 0
Trp 0 0 0 1 0 1 0 0
Ser 0 0 0 0 1 0 1 0
Thr 0 0 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 1 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 1 0 0 0 0 0
Glu 0 0 1 1 1 2 0 0
Lys 0 0 2 1 1 1 0 0
Arg 0 0 4 9 2 1 0 0
His 0 0 1 0 1 2 1 2
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
DPP3 11q12-q13.1 ENSG00000174483 10072 DPP3 606818
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Dpp3 19:A ENSMUSG00000006464 98163 MGI:1922471