Summary for peptidase S01.001: chymotrypsin A (cattle-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namechymotrypsin A (cattle-type)
Other namesalpha chymotrypsin (Bos)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.001
Holotypechymotrypsin A (cattle-type) (Bos taurus), Uniprot accession P00766 (peptidase unit: 34-263), MERNUM MER0000002
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00264
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.1
EnzymologyBRENDA database
Proteolytic eventsCutDB database (13 cleavages)
BiotechnologyShows promise for the synthesis of peptides in non-aqueous solvents.
PhysiologyContributes to digestion of food proteins in the mammalian intestine.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/yflScissile bond-/-/-/- (based on 1057 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 125 105 110 0 87 68 111 104
Pro 69 30 76 1 8 66 74 78
Ala 132 125 91 3 91 90 82 77
Val 98 73 63 1 83 54 47 37
Leu 83 34 112 274 113 94 77 88
Ile 37 55 68 2 67 38 41 28
Met 17 23 5 41 20 17 14 12
Phe 33 19 13 280 12 36 31 30
Tyr 18 19 36 296 9 43 43 19
Trp 5 3 3 63 5 6 7 9
Ser 63 67 67 0 106 69 71 53
Thr 39 87 74 1 83 55 63 80
Cys 10 12 11 2 14 24 6 41
Asn 47 56 43 36 35 53 60 51
Gln 22 39 31 8 23 62 31 41
Asp 36 44 36 1 44 38 44 57
Glu 51 86 50 9 42 62 45 60
Lys 62 103 120 2 132 88 110 106
Arg 65 57 30 1 46 44 44 33
His 18 8 9 36 9 17 22 21