Summary for peptidase S08.071: furin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namefurin
Other namesdibasic processing enzyme, Tachypleus kexin, PACE, PCSK3 peptidase, prohormone convertase, SPC1, prohormone convertase 3, proprotein convertase subtilisin/kexin type 3
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.071
Holotypefurin (Homo sapiens), Uniprot accession P09958 (peptidase unit: 131-421), MERNUM MER0000375
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00358
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.75
EnzymologyBRENDA database
Proteolytic eventsCutDB database (89 cleavages)
Activity statushuman: active (Creemers & Van de Ven, 2004)
mouse: active (by similarity)
BiotechnologyProposed for use in processing of recombinant proteins.
PhysiologyProcesses numerous proproteins in the secretory pathway by cleavage at paired basic amino acids.
KnockoutMouse embryos lacking furin die at about 11 days with severe heart defects (Roebroek et al., 1998).
Pathways KEGGInfluenza A
Other databases TREEFAMhttp://www.treefam.org/family/TF314277
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternR/-/Kr/RScissile bonds/v/-/- (based on 208 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 5 1 0 15 3 21 19
Pro 0 2 9 0 2 7 9 15
Ala 4 11 8 0 23 34 12 17
Val 5 8 4 0 2 46 4 8
Leu 5 10 3 1 5 31 14 14
Ile 8 6 1 0 0 15 9 3
Met 0 2 0 0 2 1 1 5
Phe 7 5 0 0 12 6 5 5
Tyr 1 0 0 0 9 0 4 4
Trp 0 4 0 0 1 3 1 0
Ser 2 27 6 0 57 12 30 19
Thr 0 18 6 0 2 13 11 14
Cys 0 0 0 0 4 0 2 1
Asn 0 7 1 0 1 3 7 7
Gln 1 18 3 0 6 2 9 7
Asp 2 2 0 0 22 5 18 15
Glu 1 9 4 0 20 1 16 16
Lys 7 34 88 4 7 10 7 14
Arg 158 26 68 203 7 7 14 11
His 2 8 5 0 6 3 4 6
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
FURIN 15q25-q26 ENSG00000140564 5045 PACE 136950
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pcsk3 7:D1-E2 ENSMUSG00000030530 18550 MGI:97513