Statistics for the MEROPS Database

Counts are for peptidases and their homologues, and sequences of the same, that are included in MEROPS.

Contents

  1. Totals for all catalytic types
  2. Aspartic peptidases
  3. Cysteine peptidases
  4. Glutamic peptidases
  5. Metallopeptidases
  6. Asparagine peptidases
  7. Serine peptidases
  8. Threonine peptidases
  9. Peptidases of unknown catalytic type
  10. Unclassifiable peptidases

TOTALS FOR ALL CATALYTIC TYPES
Catalytic Type Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
Aspartic 43900 317 32 64
Cysteine 175765 993 78 228
Glutamic 396 7 2 3
Metallo 293668 1061 132 282
Asparagine 3878 24 3 22
Mixed 6974 53 0 8
Serine 333043 1693 119 343
Threonine 34643 99 6 47
Unknown 9941 19 0 8
Unclassifiable 4 3 24 -
Grand Total 902212 4269 396 1005
Total Families 264
Total clans 62
Aspartic Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
AA A1 pepsin A 16022 183 22 36
AA A2 HIV-1 retropepsin 1396 51 3 14
AA A3 cauliflower mosaic virus-type peptidase 61 6 0 -
AA A9 spumapepsin 18 1 0 1
AA A11 Copia transposon peptidase 3569 6 0 -
AA A28 DNA-damage inducible protein 1 2979 13 0 3
AA A32 PerP peptidase (Caulobacter sp.) 630 2 0 1
AC A8 signal peptidase II 6498 1 1 1
AD A22 presenilin 1 3673 31 0 3
AD A24 type 4 prepilin peptidase 1 6160 8 1 1
AE A25 gpr peptidase 323 1 1 1
AE A31 HybD peptidase 2039 6 1 1
AF A26 omptin 143 5 2 2
unassigned A5 thermopsin 102 1 1 -
unassigned A36 sporulation factor SpoIIGA 228 1 0 -
unassigned A37 sso1175 g.p. (Sulfolobus solfataricus) 59 1 0 -
Cysteine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
CA C1 papain 15685 226 26 42
CA C2 calpain-2 6516 38 3 6
CA C6 family S30 unassigned peptidases 216 2 1 1
CA C10 streptopain 230 4 1 2
CA C12 ubiquitinyl hydrolase-L1 3104 21 1 4
CA C16 murine hepatitis coronavirus papain-like peptidase 1 73 10 0 3
CA C19 ubiquitin-specific peptidase 14 25601 180 1 21
CA C28 foot-and-mouth disease virus L-peptidase 29 2 1 1
CA C31 family S32 unassigned peptidases 19 1 0 1
CA C32 porcine reproductive and respiratory syndrome virus nsp4 peptidase 29 3 0 1
CA C33 equine arteritis virus Nsp2-type cysteine peptidase 14 1 0 1
CA C39 bacteriocin-processing peptidase 3682 8 0 1
CA C47 staphopain A 28 4 1 2
CA C51 D-alanyl-glycyl peptidase (staphylococcal phage phi11-type) 214 3 0 1
CA C54 autophagin-1 1811 18 0 2
CA C58 YopT peptidase 51 6 0 2
CA C64 Cezanne peptidase 1326 6 0 4
CA C65 otubain-1 1212 4 0 3
CA C66 IdeS peptidase 60 3 0 1
CA C67 CylD peptidase 532 4 0 2
CA C70 AvrRpt2 peptidase 9 1 0 -
CA C71 pseudomurein endoisopeptidase Pei 2 1 0 -
CA C76 viral tegument protein deubiquitinylating peptidase 40 1 0 1
CA C78 UfSP1 peptidase 897 6 0 2
CA C83 gamma-glutamylcysteine dipeptidyltranspeptidase 633 5 0 1
CA C85 OTLD1 deubiquitinylating enzyme 3534 16 0 5
CA C86 ataxin-3 1271 10 0 2
CA C87 nairovirus deubiquitinylating peptidase 14 1 0 1
CA C93 LapG peptidase (Pseudomonas fluorescens) 297 1 0 1
CA C96 McjB peptidase 171 1 0 -
CA C98 USPL1 peptidase 209 1 0 -
CA C100 agglutinin peptidase (Marasmius oreades) 5 1 0 2
CA C101 OTULIN peptidase 349 1 0 1
CA C102 GtgE peptidase 1 1 0 1
CA C104 PlyC phage lysin 27 1 0 1
CA C105 family S32 unassigned peptidases 1 1 0 -
CA C110 kyphoscoliosis peptidase 1326 1 0 -
CA C111 coagulation factor XIIIa 2746 2 0 1
CA C113 IgdE peptidase (Streptococcus suis) 90 1 0 -
CA C115 MINDY-1 protein 1207 2 0 -
CA C117 SpvD g.p. (Salmonella enterica) 8 1 0 1
CD C11 clostripain 464 4 1 1
CD C13 legumain (plant beta form) 2151 12 1 1
CD C14 caspase-1 6109 59 11 15
CD C25 gingipain RgpA 466 4 2 3
CD C50 separase (yeast-type) 886 7 1 -
CD C80 RTX self-cleaving toxin 101 3 0 2
CD C84 prtH peptidase (Tannerella forsythensis ATCC 43037) 13 1 0 -
CE C5 adenain 92 1 1 1
CE C48 Ulp1 peptidase 5954 57 1 5
CE C55 YopJ protein 90 8 0 -
CE C57 vaccinia virus I7L processing peptidase 34 1 0 -
CE C63 African swine fever virus processing peptidase 1 1 0 -
CE C79 ElaD peptidase (Escherichia-type) 90 1 0 -
CF C15 pyroglutamyl-peptidase I (prokaryote) 2523 9 1 1
CL C60 sortase A (Staphylococcus-type) 1956 9 2 5
CL C82 L,D-transpeptidase (Enterococcus-type) 9783 8 0 2
CM C18 hepacivirin 197 2 0 1
CN C9 sindbis virus-type nsP2 peptidase 44 2 0 2
CO C40 dipeptidyl-peptidase VI (bacteria) 13452 20 0 3
CP C97 DeSI-1 peptidase 2438 14 0 1
CQ C53 pestivirus Npro peptidase 49 2 0 2
unassigned C7 chestnut blight fungus virus p29 peptidase 7 1 0 -
unassigned C8 chestnut blight fungus virus p48 peptidase 6 1 0 -
unassigned C21 tymovirus peptidase 33 1 0 1
unassigned C23 carlavirus peptidase 44 1 0 -
unassigned C27 rubella virus peptidase 1 1 0 -
unassigned C36 beet necrotic yellow vein furovirus-type papain-like peptidase 3 1 0 -
unassigned C42 beet yellows virus-type papain-like peptidase 10 4 0 -
unassigned C75 AgrB peptidase 119 2 0 -
unassigned C108 Prp peptidase (Staphylococcus aureus) 833 2 0 2
unassigned C116 2 1 0 1
PA C3 poliovirus-type picornain 3C 679 19 2 11
PA C4 potyvirus P1 peptidase 217 14 1 1
PA C24 rabbit hemorrhagic disease virus 3C-like peptidase 26 3 0 1
PA C30 porcine transmissible gastroenteritis virus-type main peptidase 96 6 1 5
PA C37 calicivirin 37 2 1 2
PA C62 gill-associated virus 3C-like peptidase 2 1 0 -
PA C74 pestivirus Npro peptidase 26 1 0 2
PA C99 iflavirus processing peptidase 3 1 0 -
PA C107 alphamesonivirus 3C-like peptidase 8 1 0 -
PB C44 amidophosphoribosyltransferase precursor 11342 16 3 7
PB C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase precursor 1106 2 0 1
PB C59 penicillin V acylase precursor 2011 2 1 2
PB C69 dipeptidase A 2376 6 0 -
PB C89 acid ceramidase precursor 691 4 0 -
PB C95 lysosomal 66.3 kDa protein (Mus musculus-type) 795 2 0 2
PC C26 gamma-glutamyl hydrolase 20048 41 11 12
PC C56 PfpI peptidase 13892 17 2 8
PD C46 hedgehog protein 1190 15 0 4
Glutamic Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
GA G1 scytalidoglutamic peptidase 268 6 2 2
GB G2 pre-neck appendage protein (Bacillus phage phi29) 128 1 0 1
Metallo Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
MA M1 aminopeptidase N 14653 64 9 12
MA M2 angiotensin-converting enzyme peptidase unit 2 1411 9 2 4
MA M3 thimet oligopeptidase 10552 17 6 8
MA M4 thermolysin 2480 23 6 5
MA M5 mycolysin 22 1 1 -
MA M6 immune inhibitor A peptidase (Bacillus sp.) 1148 3 0 1
MA M7 snapalysin 109 1 0 1
MA M8 leishmanolysin 1724 11 1 1
MA M9 bacterial collagenase V 349 4 1 1
MA M10 matrix metallopeptidase-1 7568 66 12 21
MA M11 gametolysin 149 3 1 -
MA M12 astacin 17637 234 30 33
MA M13 neprilysin 8062 48 2 4
MA M26 IgA1-specific metallopeptidase 289 4 1 -
MA M27 tentoxilysin 44 3 2 3
MA M30 hyicolysin 143 1 0 -
MA M32 carboxypeptidase Taq 1788 6 1 4
MA M34 anthrax lethal factor 72 2 1 2
MA M35 deuterolysin 265 5 2 3
MA M36 fungalysin 775 1 0 1
MA M41 FtsH peptidase 11559 37 0 7
MA M43 cytophagalysin 1785 6 1 1
MA M48 Ste24 peptidase 12399 22 1 4
MA M49 dipeptidyl-peptidase III 1076 10 1 2
MA M54 archaelysin 779 3 0 1
MA M56 BlaR1 peptidase 2747 3 0 2
MA M57 prtB g.p. (Myxococcus xanthus) 58 1 0 -
MA M60 enhancin 164 5 0 -
MA M61 glycyl aminopeptidase 3401 2 0 -
MA M64 IgA peptidase (Clostridium ramosum-type) 106 1 0 1
MA M66 StcE peptidase 186 1 0 1
MA M72 peptidyl-Asp metallopeptidase 113 1 1 -
MA M76 Atp23 peptidase (animal-type) 870 5 0 -
MA M78 ImmA peptidase 2061 2 0 1
MA M80 Wss1 peptidase 337 5 0 -
MA M84 MpriBi peptidase (Bacillus sp.) 29 1 0 -
MA M85 NleC peptidase (Escherichia coli) 12 1 0 1
MA M90 MtfA peptidase 1056 1 0 1
MA M91 NleD peptidase (Escherichia coli-type) 10 1 0 -
MA M93 BACCAC_01431 g.p. (Bacteroides caccae) and similar 233 1 0 -
MA M95 selecase (Methanocaldococcus jannaschii) 4 1 0 1
MA M97 EcxAB peptidase 170 1 0 1
MA M98 YghJ g.p. (Escherichia coli) 403 3 0 -
MA M100 0 0 0 -
MC M14 carboxypeptidase A1 12386 74 11 12
MC M86 PghP gamma-polyglutamate hydrolase (bacteriophage) 154 1 0 1
MC M99 Csd4 peptidase (Helicobacter pylori) 1 1 0 1
MD M15 zinc D-Ala-D-Ala carboxypeptidase (Streptomyces-type) 5883 13 3 6
MD M74 murein endopeptidase 377 1 0 1
ME M16 pitrilysin 20037 57 4 18
ME M44 pox virus metallopeptidase 41 1 0 -
MF M17 leucine aminopeptidase 3 5715 21 3 6
MG M24 methionyl aminopeptidase 1 (Escherichia-type) 14521 37 3 19
MH M18 aminopeptidase I 3097 6 2 4
MH M20 glutamate carboxypeptidase 38060 44 10 18
MH M28 aminopeptidase S (Streptomyces-type) 6947 46 4 13
MH M42 glutamyl aminopeptidase (bacterium) 4126 12 0 8
MJ M19 membrane dipeptidase 4694 12 1 5
MJ M38 isoaspartyl dipeptidase (metallo-type) 24039 14 5 12
MM M50 site 2 peptidase 9879 19 1 2
MN M55 D-aminopeptidase DppA 758 2 0 1
MO M23 beta-lytic metallopeptidase 10379 18 2 9
MP M67 RPN11 peptidase 7406 29 0 12
MQ M29 aminopeptidase T 2614 4 0 2
MS M75 imelysin 329 1 0 1
MT M81 microcystinase MlrC 559 1 0 1
unassigned M73 camelysin 193 2 0 -
unassigned M77 tryptophanyl aminopeptidase 7-DMATS-type peptidase 197 4 1 1
unassigned M79 RCE1 peptidase (Saccharomyces cerevisiae-type) 9329 11 0 1
unassigned M82 PrsW peptidase 1375 1 0 -
unassigned M87 chloride channel accessory protein 1 684 6 0 -
unassigned M88 IMPa peptidase (Pseudomonas aeruginosa) 31 1 0 -
unassigned M96 Tiki1 peptidase 1059 2 0 -
Asparagine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
NA N1 nodavirus peptide lyase 8 1 1 2
NA N2 tetravirus coat protein 7 1 0 2
NA N8 poliovirus-type picornain 3C 868 1 0 2
NB N6 YscU protein 1890 5 0 3
NC N7 reovirus type 1 coat protein 22 2 0 1
ND N4 Tsh peptidase 456 2 0 3
NE N5 picobirnavirus self-cleaving protein 6 1 0 1
PD N9 intein-containing V-type proton ATPase catalytic subunit A 89 1 1 1
PD N10 intein-containing replicative DNA helicase precursor 458 9 1 7
PD N11 peptidase Clp (type 7) 74 1 0 -
Mixed Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PB P2 EGF-like module containing mucin-like hormone receptor-like 2 6282 48 0 4
PE P1 DmpA aminopeptidase 692 5 0 4
Serine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PA S1 chymotrypsin A (cattle-type) 57717 691 52 131
PA S3 togavirin 62 1 1 1
PA S6 IgA1-specific serine peptidase (Neisseria-type) 297 11 1 4
PA S7 flavivirin 124 2 1 3
PA S29 hepacivirin 213 2 1 2
PA S30 potyvirus P1 peptidase 77 2 0 -
PA S31 pestivirus NS3 polyprotein peptidase 32 1 0 1
PA S32 equine arteritis virus serine peptidase 31 2 0 2
PA S39 sobemovirus peptidase 66 2 0 1
PA S46 dipeptidyl-peptidase 7 (Porphyromonas gingivalis-type) 1052 3 0 2
PA S55 SpoIVB peptidase 334 1 1 -
PA S64 Ssy5 peptidase 40 1 0 -
PA S65 picornain-like cysteine peptidase (Breda-1 torovirus) 2 1 0 -
PA S75 White bream virus serine peptidase 1 1 0 -
PB S45 penicillin G acylase precursor 2584 4 1 5
PC S51 dipeptidase E 2556 3 2 3
RM S58 0 0 0 -
SB S8 subtilisin Carlsberg 28635 209 13 38
SB S53 sedolisin 2643 13 5 4
SC S9 prolyl oligopeptidase 47586 205 15 34
SC S10 carboxypeptidase Y 10319 87 3 7
SC S15 Xaa-Pro dipeptidyl-peptidase 6075 1 1 2
SC S28 lysosomal Pro-Xaa carboxypeptidase 3644 31 2 2
SC S33 prolyl aminopeptidase 28477 150 9 21
SC S37 PS-10 peptidase 49 1 0 -
SE S11 D-Ala-D-Ala carboxypeptidase A 12906 11 1 6
SE S12 D-Ala-D-Ala carboxypeptidase B 24258 32 2 9
SE S13 D-Ala-D-Ala peptidase C 2930 6 1 2
SF S24 repressor LexA 9961 6 1 3
SF S26 signal peptidase I 14902 34 1 2
SH S21 cytomegalovirus assemblin 73 6 1 5
SH S73 gpO peptidase (Enterobacteria phage P2) 338 1 0 -
SH S77 prohead peptidase gp21 (bacteriophage T4) 34 1 0 -
SH S78 prohead peptidase (bacteriophage HK97) 1517 2 0 -
SH S80 prohead peptidase gp175 (Pseudomonas aeruginosa phage phiKZ) 6 1 0 -
SJ S16 Lon-A peptidase 17796 25 1 7
SJ S50 infectious pancreatic necrosis birnavirus Vp4 peptidase 25 4 0 2
SJ S69 Tellina virus 1 VP4 peptidase 1 1 0 1
SK S14 peptidase Clp (type 1) 12819 15 1 11
SK S41 C-terminal processing peptidase-1 11521 19 1 5
SK S49 signal peptide peptidase A 8694 9 0 3
SO S74 Escherichia coli phage K1F endosialidase CIMCD self-cleaving protein 71 2 0 2
SP S59 nucleoporin 145 1336 11 0 4
SR S60 lactoferrin 1140 11 0 5
SS S66 murein tetrapeptidase LD-carboxypeptidase (Pseudomonas-type) 3669 3 1 3
ST S54 rhomboid-1 (Diptera) 14139 52 0 3
unassigned S48 HetR putative peptidase 88 1 0 1
unassigned S62 influenza A PA peptidase 56 1 0 1
unassigned S68 PIDD auto-processing protein unit 1 180 2 0 -
unassigned S71 MUC1 self-cleaving mucin 692 2 0 1
unassigned S72 dystroglycan 367 2 0 1
unassigned S79 CARD8 self-cleaving protein 542 7 0 2
unassigned S81 destabilase 366 1 0 1
Threonine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PB T1 archaean proteasome, beta component 17968 60 2 37
PB T2 glycosylasparaginase precursor 4132 9 1 6
PB T3 gamma-glutamyltransferase 1 (bacterial-type) 8349 26 2 2
PB T7 CwpV (Clostridium difficile) self-cleaving threonine peptidase 5 1 0 -
PE T5 ornithine acetyltransferase precursor 3816 2 1 2
unassigned T8 HopB1 g.p. (Pseudomonas syringae) 373 1 0 -
Unknown Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
unassigned U32 collagenase (Porphyromonas-type) 2729 6 0 2
unassigned U40 protein P5 murein endopeptidase (bacteriophage phi-6) 2 1 0 -
unassigned U49 Lit peptidase 10 1 0 -
unassigned U50 0 0 0 -
unassigned U56 homomultimeric peptidase 233 1 0 1
unassigned U57 yabG protein (Bacillus-type) 204 1 0 -
unassigned U62 microcin-processing peptidase 1 3316 4 0 3
unassigned U69 AIDA-I self-cleaving autotransporter protein (Escherichia coli) 661 2 0 2
unassigned U72 Dop isopeptidase 536 1 0 -
unassigned U73 small protease (Pseudomonas aeruginosa) 14 1 0 -
unassigned U74 neprosin 2236 1 0 -
Unclassifiable Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
unassignable unassignable 4 3 24 -